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IU-MSI STEM Initiative

Travis Jerde

pharmtox.iusm.iu.edu/faculty/travis-jerde-ph-d/

Inflammation may be a key trigger of carcinogenesis and tumor growth, and tumor cells show many physical and molecular features common during organ development. We have found that inflammatory mediators are highly expressed during normal development and play a significant role in organ development by promoting proliferation. Interleukin-1 induces proliferation during prostate development and inflammatory repair working through developmental mediators such as insulin-like growth factors (IGFs) and transforming growth factors (TGFs). These results demonstrate clear interplay between inflammatory and developmental signaling networks. We now seek to understand how these signaling interactions promote epithelial proliferation and allow damaged cells to escape cell death in the inflamed prostate. Currently, my lab has three main specific projects:

  • The role of IGF-1 in inflammation-induced epithelial survival and proliferation,
  • Investigating small heat-shock chaperones that promote apoptotic or autophagic escape during inflammatory reactive hyperplasia in the prostate, and
  • Investigating how androgen and IL-1 cooperatively promote prostatic growth by STAT-3 dependent IGF-1 signaling

Revised: Dec. 6, 2014

Sarah Larson
Program Coordinator
IU-MSI STEM Initiative
Indiana University
set9@indiana.edu
812-855-7463