Indiana University

IU-MSI STEM Initiative

Heather Bradshaw

www.bryteideas.org/

The two fields that I have a passion for are the neuroscience of reproduction and the biochemistry of lipid signaling. My group combines these fields to understand nervous system control of female reproductive neurophysiology and behavior by lipid signaling. One lipid signaling system currently being investigated centers on endogenous cannabinoids. Cannabinoids are the active compounds in the plant cannabis. Cannabinoid compounds activate receptors throughout the body and the nervous system and regulate a myriad of neurophysiological pathways. These receptors did not evolve to prepare for the likelihood that an organism would someday ingest compounds from a cannabis plant. They evolved in concert with endogenous signaling molecules that are collectively called endocannabinoids. The most studied of these are the lipid signaling molecules, anandamide (AEA) and 2-arachidonoyl glycerol (2-AG). There is, however, growing evidence that these two lipids are not alone in exerting cannabimimetic (cannabinoid-like) effects in the body. Many of these novel endogenous endocannabinoid analogs are produced in the female reproductive tract and the brain. What are they doing there?! Well, that's what we are in the process of finding out. Of particular interest to my group is their involvement in the neurophysiology of pelvic pain. Lipid signaling molecules have a long history of being involved in pain and inflammation. NSAIDs (non-steroidal anti-inflammatory drugs) such as aspirin and ibuprofen (Advil) block the production of the lipid signaling molecules from the family called Prostaglandins. Prostaglandins, like endocannabinoids, are made with a fatty acid, arachidonic acid, and so share structural similarity. We have multiple lines of research ongoing that will lead us to a greater understanding of the following: 1) the neurophysiological role of endogenous cannabinoids in the regulation of uterine contractions, 2) the biochemical role of endogenous cannabinoids in regulating cell migration of endometrial cells within the reproductive tract and how this communication plays a role in pelvic pain disorder, endometriosis, 3) how steroid hormones regulate the production and activity of these lipid signaling molecules, and 4) how the biochemistry and neurophysiology of this family of lipids acting on the reproductive tract and the brain ultimately shape behaviors.

Revised: Feb. 22, 2012

Sarah Larson
Program Coordinator
IU-MSI STEM Initiative
Indiana University
set9@indiana.edu
812-855-7463